Immunotherapy is promising in clinical antitumor treatment, especially for recurrent or metastasized cancer, which is an acknowledged clinical difficulty. Collectively, our work not only demonstrates a method for constructing a new nanoplatform for photothermal therapeutics but also provides a general strategy for synchronously activating innate and adaptive immunities to promote the maturation of DCs for antimetastasis tumor therapy. Furthermore, in an osteosarcoma model, we observed that the proposed nanoplatform leads to the effective presentation of tumor antigens, which boost the maturation of dendritic cells (DCs) to the hilt and thus improve the infiltration of cytotoxic T lymphocyte in primary and distant tumors. More importantly, the released mt-DNA and Mn 2+ synergistically activate innate immunity via the cGAS-stimulator of the interferon genes signaling pathway, and the OVA and protein antigens from tumor cells enhance adaptive immunity. The nanoplatform was formed by linking titanium carbide MXene with Mn 2+-contained ovalbumin (OVA), where it can trigger efficient mt-DNA presentation and the release of OVA and Mn 2+ upon the irradiation of near-infrared laser. Herein, we offer a new approach to achieve a cross-talk between innate and adaptive immune responses based on a new nanoplatform for photothermal therapeutics.

Inadequate immune response remains a critical cause of immunotherapy failure in various tumor treatments.

Optimizing 3d max 2015